Transcription factor C/EBPb isoform ratio regulates osteoclastogenesis through MafB
نویسندگان
چکیده
Jeske J Smink, Valérie Bégay, Ton Schoenmaker, Esta Sterneck, Teun J de Vries and Achim Leutz* Max Delbrueck Center for Molecular Medicine, Berlin, Germany, Departments of Periodontology and Oral Cell Biology, Academic Centre of Dentistry Amsterdam, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands and National Cancer Institute, Center for Cancer Research, Frederick, MD, USA
منابع مشابه
Transcription factor C/EBPβ isoform ratio regulates osteoclastogenesis through MafB
Disequilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts is central to many bone diseases. Here, we show that dysregulated expression of translationally controlled isoforms of CCAAT/enhancer-binding protein beta (C/EBPbeta) differentially affect bone mass. Alternative translation initiation that is controlled by the mammalian target of rapamycin (mTOR) pathway generates lo...
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Receptor activator of nuclear factor kappaB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors. Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation. Expression levels of MafB are significantly reduced by RANKL during osteoclastogenesis. Overexpression of MafB in bone marrow-derived monocyte/macro...
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MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes. During osteoclastogenesis, its expression is downregulated at the transcriptional level via the JNK and p38 MAP kinase pathways. In the present study, we demonstrated that MafB protein stability is regulated by JNK and identified a phosphorylation site, Thr62. The express...
متن کاملMafB negatively regulates RANKL-mediated osteoclast differentiation (Short title: The negative role of MafB in osteoclastogenesis)
To whom correspondence should be addressed: Nacksung Kim, Ph.D. Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak-Dong 5, Dong-Ku, Gwangju 501-746, Korea. Phone: 82-62-220-4418, Fax: 82-62-223-4018, E-mail: [email protected] Contribution K.Kim, J.H.Kim, J.Lee, and H.M.Jin : performed research and analyzed data H.Kook : contributed vital reagents K.K.K...
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Epithelial–mesenchymal transition (EMT) is a developmental program that is associated with esophageal squamous cell carcinoma (ESCC) progression and metastasis. Recently, C/EBPb has been reported to be an EMT inducer in cancer. However, the detailed molecular mechanisms remain unclear. Here, we report for the first time, that the truncated CCAAT-enhancer-binding protein b (C/EBPb) LIP isoform i...
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